Months ago, we featured stem cells as a possible key to curing Type 1 diabetes. This time, a new research sheds light into the possibility of doing the same for Type 2 diabetes.
Lab tests done on mice with Type 2 diabetes revealed that glucose metabolism improved after transplanting stem cells from the pancreas combined with drugs that sensitize insulin. The tests were also conducted to assess the impact of stem cells on obesity, which yielded promising results. “Our data suggest that transplanted human embryonic stem cell (hESC)-derived insulin-producing cells thrive following chronic exposure to high-fat diets, at least in immunodeficient mice… Thus, stem cells are candidates for restoring functional beta cells in an insulin-resistant, obese setting,” according to researchers from the University of British Columbia.
The scientists conducted several tests to check which insulin-sensitizing drug could maximize the effect of stem cells on diabetes and obesity. “The reversal of hyperleptinemia in both sitagliptin- and metformin-treated transplant recipients also suggests a more robust reversal of the obesity phenotype in these groups as compared with the high-fat diet transplant recipients treated with rosiglitazone or without drugs,” the researchers said in a news release.
The study was co-authored by Timothy J. Kieffer, who works as Diabetes Research Group Leader and professor of the university. The research paper was published in the Stem Cell Reports journal.