When blood pressure drugs no longer work to control the blood pressure of some patients, nitric oxide supplements may be of help, as suggested by a new research.
In a study published online in the American Journal of Human Genetics, researchers said that nitric oxide supplements were able to manage treatment-resistant hypertension in a patient with argininosuccinic aciduria (ASA).
Brendan Lee, PhD, of the Baylor College of Medicine, shared that treatment with inorganic nitric oxide supplements helped normalize blood pressure levels. The researchers wrote: “Our results support the contention that the investigation of nitric oxide supplementation in ASA subjects should be performed in a systematic manner.”
They added: “Our results confirm that the vascular dysfunction seen with argininosuccinate lyase deficiency is independent of the metabolic defect in the urea cycle, is directly associated with nitric oxide deficiency in the vasculature, and can be rescued by a nitric oxide synthase-independent nitric oxide source in vivo.”