Early Disease Detection Health & Wellness Substance Abuse

Experts Study the Benefits of Kratom for Treating Drug Abuse Withdrawal Symptoms

A team of experts is conducting preclinical studies that will determine the value of Kratom in treating substance abuse withdrawal symptoms in humans.

School of Pharmacy faculty member Christopher R. McCurdy and his colleagues isolated Kratom’s most abundant alkaloid, mitragynine, and tested the pure compound. They found that the compound’s activity is superior to methadone when tested in mice habituated to morphine and that carefully created variations may provide an alternative to methadone in treating addictions to opiates, according to the Medical Xpress report.

“Mitragynine completely blocked all withdrawal symptoms and could provide a remarkable step-down-like treatment for people addicted to hardcore narcotics such as morphine, oxycodone or heroin,” McCurdy explained. “The compound has been known for years, but we’re working to come up with an improved synthetic analog or a better formulation of the tea for testing in humans.”

Collaborating on the study is Dr. Edward W. Boyer, an opium treatment specialist and a professor of emergency medicine and director of medical toxicology at the University of Massachusetts School of Medicine.

McCurdy said Dr. Boyer has been instrumental in gathering the information they needed in determining the dosages and frequencies of Kratom use for their animal studies.

The clinicians also analyzed a sample by a patient, who had been using Kratom four times a day for more than three years, arriving with seizures at the University of Colorado emergency room. They found that the seizures resulted from co-administration of Modafinil and not due to Kratom use.

“We have been able to distinguish the effects of kratom from those of other drugs whose presence was unanticipated,” Dr. Boyer said. “This has allowed us to document that some toxicity of kratom is actually from other pharmaceutical agents that had been added.”

Kratom, a tropical tree native to Southeast Asia, has been listed by the U.S. Drug Enforcement Administration as a “drug of concern” because of its abuse potential. But for the several millions of Americans, Kratom helps them manage chronic pains and deal with opioid withdrawal.

“There’s still a long way to go, but our research team is motivated to complete the preclinical studies necessary to allow us to start doing human studies,” McCurdy added.


  1. kratom health benefits

    kratom helps you to be active all through the day and it will improve your confidence level as well.

  2. Jesse Ryan

    Awesome article! I have Fibromyalgia and was first prescribed Vicodin when I was 13. …… When I was 17 doctors put me on 60 mg's of Morphine Sulfate every eight hours, and 10 mg's of Valium twice a day. After opiate medications stopped working for me I ended up in a methadone clinic trying to wean off of the pain meds I was prescribed. Long story short it didn't work, Methadone is actually a much more painful and longer lasting withdrawal than any other opiate I have ever been on. I would rather detox off of black tar heroine than methadone. Now I no longer have to make decisions like that though because I wake up and take one dose of kratom every morning. That keeps my fibromyalgia symptoms at bay until the next morning. The best part about it isn't that I can finally hold down a job, or because I don't have to choose between crippling pain or feeling sedated ( both make work hard ) but rather because I don't have to take the kratom if I don't want to. If I wake up and feel alright I don't have to worry about taking my medication before I go into withdrawal like I did with morphine. Literally one day without morphine when you take it daily, and you will go straight into physical withdraw (puking, cramps, diarrhea, runny nose, no energy and last but not least, depression ) Kratom gives me the freedom to live a"normal" life free from addictive pain killers and pain. I thank God for creating this plant & pray that I always have access to it. Kratom is a much better alternative than leading another generation of young Americans into opiate addiction.

  3. Earnest R. Estrada

    Its good to see the kind of interest shown by you on the drug addicted persons. Some sites like kratomlegend has been upgrading techniques to replace these kind of drugs with some natural medical plants like the kratom. They are already available online to purchase.

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